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KMID : 1189420220350010001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2022 Volume.35 No. 1 p.1 ~ p.10
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Anti-inflammatory Effects of Aster glehni Water Extracts in LPS-stimulated RAW 264.7 Macrophages
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Ko Ho-Geon
Lee Kyou-Young
Hong Chul-Hee
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Abstract
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Objectives : This study was conducted to confirm the anti-inflammatory effects of Aster glehni Water extracts.
Methods : In this study, MTT assay was performed to detect cell viability. To evaluate the anti-inflammatory effects of Aster glehni Water extracts, we examined NO production in LPS-induced macrophages. Expressions of iNOS, COX-2, ERK, p38, JNK were also investigated by using western blot assay.
Results : Aster glehni Water extracts have no cytotoxicity at 15.625-1,000㎍/㎖ in RAW 264.7 cells. Aster glehni Extracts inhibited the NO production in a dose-dependent manner in RAW 264.7 cells treated with LPS.
Pretreated 250, 500, 1,000㎍/㎖ of Aster glehni water extracts had significantly suppressed expression levels of iNOS, COX-2, p-ERK, p-p38, p-JNK.
Conclusions : These results suggest that Aster glehni Water extracts have anti-inflammatory effects and can be used for various inflammatory skin diseases.
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KEYWORD
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Aster glehni, Anti-inflammation, iNOS, COX-2, MAPK
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